Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology based approach
Published:
K. Hari, B. Sabuwala, B. V. Subramani, C. A. M. La Porta, S. Zapperi, F. Font-Clos, M. K. Jolly, Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology based approach, npj Syst. Biol. Appl. 6 (15)
Download PDF here
Abstract: We investigate the dynamics of various regulatory networks implicated in Epithelial-Mesenchymal Plasticity (EMP) through two different mathematical modelling frameworks: a discrete, parameter-independent framework (Boolean) and a continuous, parameter-agnostic modelling framework (RACIPE). Results from either framework in terms of phenotypic distributions obtained from a given EMP network are qualitatively similar and suggest that these networks are multi-stable and can give rise to phenotypic plasticity.